To Breathe or Not to Breathe: The Role of Oxygen in Bone Marrow-Derived Mesenchymal Stromal Cell Senescence

Stem cell-based cellular therapy is a promising tool for the treatment of pathological conditions with underlying severe tissue damage or malfunction like in chronic cardiovascular, musculoskeletal, inflammatory conditions. One biggest technical challenges use natural stem cells, however, prevention their premature senescence during therapeutical manipulations. Culturing cells under hypoxic believed to be possible route fulfill this goal. Here, we review current literature data on effects hypoxia bone marrow-derived mesenchymal stromal one most popular tools practical therapy, context senescence.